Protein losing enteropathy (PLE) is a symptom of many different gastrointestinal (GI) diseases. It varies in severity and is more common in dogs than cats. Learn all about PLE, what it means, what conditions can cause it and most importantly, what we can do to help our patients! PLE has a variety of presenting signs and there are many ways that we can impact the care we provide in hospital. It carries many life threatening complications and the more we know, the more we can step in to intervene and improve the patients outcome.