Sepsis is a common condition affecting a huge number of veterinary patients throughout the UK and the world. It is the biggest killer of people of all ages and it is widely accepted that this is true for animals too. Registered Veterinary Nurses (RVNs) are a valuable part of the veterinary team, and by ensuring we remain up to date with the latest information on sepsis recognition, we can communicate better with vets and together provide the best care possible for these patients. By spending time with critically unwell patients, nurses may notice when a patient starts to behave out of character; or when clinical parameters start to trend in unfavourable directions. Nurses are the advocates for these patients and recognising when they are displaying signs of sepsis can ensure the team can intervene early. Early recognition of sepsis provides the best prognosis for the patient.