Hypoadrenocorticism is an uncommon disease caused by insufficient mineralocorticoid and/or glucocorticoid production. The clinical signs are inappetence, lethargy/depression, vomiting/diarrhea, weakness, shivering, polyuria, polydipsia, collapse.

The average age at diagnosis 4-5 years and there is a female predisposition with ~70% of dogs being female. However, in some breeds there is equal male: female frequency (Bearded Collies, Portuguese Water Dogs, Nova Scotia Duck Tolling Retriever and Standard Poodles).

The disease is diagnosed by aldosterone and/or cortisol suppression on an ACTH stimulation test.

Treatment is hormonal supplementation (mineralocorticoids and glucocorticoids):

  • Either Fludrocortisone acetate
  • Or Desoxycorticosterone pivalate (DOCP) (mineralocorticoid) with Prednisolone

Prognosis is excellent once controlled.

To find out more on this topic, watch out for The Webinar Vet’s latest webinar on Hypoadrenocorticism by Sophie McMurrough RVN VTS (SAIM) on the 19th February at 8pm.

For further information on Hypoadrenocorticism check out this related content on Vetlexicon Canis:


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